BioVision Inc Monoamine Oxidase A (MAO-A) Inhibitor Screening Kit (Fluorometric): Rapid, sensitive & high-throughput assay for screening/characterizing/studying potential inhibitors of MAO A. Includes Inhibitor Control [Clorgyline]. 100 assays
Manufacturer: BioVision Inc K796100
Monoamine oxidases (MAO, EC 220.127.116.11) are a family of enzymes that can oxidize a wide variety of endogenous primary amines. Two isoforms, MAO-A and MAO-B, have been identified based on their substrate, inhibitor specificity, and tissue localization. MAO-A can oxidize primary amines such as serotonin and norepinephrine. MAO-A is a mitochondrial-bound enzyme that is ubiquitously expressed throughout the brain and other tissues. It has been implicated in panic, anxiety, and depression. Several MAO-A specific inhibitors such as clorgyline, brofaromine, toloxatone, tetrindole, etc. have been used as antidepressants, but their usage has been limited due to side effects. BioVision’s MAO-A Inhibitor Screening Kit offers a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of MAO-A inhibitors. The assay is based on the fluorometric detection of H2O2, one of the byproducts generated during the oxidative deamination of MAO substrate.
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