Invitrogen™ MAP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5140199

Catalog No. PIPA5140199

Description

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: GEGMTVGELS RALGHENGSL DPEQGMIPEM WAPMLAQALE ALQPALQCLK YKKLRVFSGR ESPEPGEEEF GRWMF.

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo. It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.

Specifications

• Antigen: MAP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MOAP1
• Gene Alias: AA987038; MAP1; Map-1; Moap1; Modulator of apoptosis 1; paraneoplastic antigen like 4; paraneoplastic antigen Ma4; paraneoplastic Ma antigen family member 4; PNMA4
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 64112
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96BY2
• Gene Symbols: MOAP1
• Immunogen: Recombinant protein corresponding to Human MOAP1. Recombinant protein control fragment (Product #RP-109603).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG