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MAP4K1 Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 239501AP

Catalog No. 50-173-4174


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Description

Description

The c-Jun amino-terminal kinases (JNKs)/stress-activated protein kinases (SAPKs) play a crucial role in stress responses in mammalian cells. The mechanism underlying this pathway in the hematopoietic system is unclear, but it is a key in understanding the molecular basis of blood cell differentiation. We have cloned a novel protein kinase, termed hematopoietic progenitor kinase 1 (HPK1), that is expressed predomitly in hematopoietic cells, including early progenitor cells. HPK1 is related distantly to the p21(Cdc42/Rac1)-activated kinase (PAK) and yeast STE20 implicated in the mitogen-activated protein kinase (MAPK) cascade. Expression of HPK1 activates JNK1 specifically, and it elevates strongly AP-1-mediated transcriptional activity in vivo. HPK1 binds and phosphorylates MEKK1 directly, whereas JNK1 activation by HPK1 is inhibited by a domit-negative MEKK1 or MKK4/SEK mutant. Interestingly, unlike PAK65, HPK1 does not contain the small GTPase Rac1/Cdc42-binding domain and does not bind to either Rac1 or Cdc42, suggesting that HPK1. activation is Rac1/Cdc42-independent. These results indicate that HPK1 is a novel functional activator of the JNK/SAPK signaling pathway.
Specifications

Specifications

MAP4K1
0.3 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q92918
HPK1, MAP4K1, MEK kinase kinase 1, MEKKK 1
Rabbit
IgG
150 μL
-20°C
Primary
11184
Immunoprecipitation, Western Blot
Unconjugated
MAP4K1
Liquid
MAP4K1
MAP4K1 Fusion Protein Ag20221
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
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