Invitrogen™ MAPKBP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA556571

Catalog No. PIPA556571

Description

Immunogen sequence: PSSPQRASGP NRHQAPSMLS PGPALSSDSD KEGEDEGTEE ELPALPVLAK STKKALASVP SPALPRSLSH WEMSRAQ Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 76%.

MAP kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. MAPKBP-1 (mitogen-activated protein kinase binding protein 1), also known as JNKBP-1, is a 1,514 amino acid protein that contains twelve WD repeats. Induced by TRAF2 (TNF receptor-associated factor 2) and Tak1 (TGF-beta-activated kinase 1), MAPKBP-1 is thought to act an adaptor protein for NFkappaB (nuclear factor kappa-B) activation. MAPKBP-1 interacts with JNK3 and may promote TRAF2 polyubiquitination. MAPKBP-1 exists as six alternatively spliced variants and is encoded by a gene located on human chromosome 15. Human chromosome 15 houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.

Specifications

• Antigen: MAPKBP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mapkbp1
• Gene Alias: 2810483F24Rik; AW123212; JNK-binding protein 1; JNKBP1; JNKBP-1; Jun N-terminal kinase binding protein 1; Jun N-terminal kinase-binding protein 1; KIAA0596; Mapkbp1; mitogen activated protein kinase binding protein 1; mitogen-activated protein kinase binding protein 1; mitogen-activated protein kinase-binding protein 1; mKIAA0596
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23005
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O60336
• Gene Symbols: Mapkbp1
• Immunogen: Recombinant protein corresponding to Human MAPKBP1. Recombinant protein control fragment (Product #RP-102575).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG