Invitrogen™ MARK1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110728

Catalog No. PIPA5110728

Description

Immunogen sequence: QEEEELKPYT EPDPDFNDTK RIDIMVTMGF ARDEINDALI NQKYDEVMAT YILLGRKPPE FEGGESLSSG NLCQRSRPSS DLNNSTLQSP AHLKVQRSIS ANQKQRRFSD HAGPSIPPAV SYTKRPQANS VESEQK.

MARK1 (MARK) is a serine/threonine kinase which is involved in cytoskeletal organization and biogenesis. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. MARK1 is involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).

Specifications

• Antigen: MARK1
• Classification: Polyclonal
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9P0L2
• Gene Symbols: MARK1
• Immunogen: Recombinant Protein corresonding to Human MARK1. Recombinant protein control fragment (Product #RP-89778).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Gene: MARK1
• Gene Alias: AW491150; B930025N23Rik; ELKL motif serine/threonine-protein kinase 3; ELKL motif serine-threonine protein kinase 3; Emk3; KIAA1477; MAP/microtubule affinity regulating kinase 1; MAP/microtubule affinity-regulating kinase 1; MARK; MARK1; mark1 {ECO:0000312; microtubule affinity regulating kinase 1; mKIAA1477; mPar-1c; PAR1 homolog c; Par1c; Par-1c; RGD:619882}; serine/threonine-protein kinase MARK1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4139
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid