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MARK3 Mouse anti-Human, Clone: OTI2D9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526759

Catalog No. PIMA526759


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Description

Description

MARK1 (MAP/microtubule affinity-regulating kinase 1) belongs to the MARK family of serine/threonine kinases. MARK family protein kinases phosphorylate microtubule-associated proteins and may play a role in cytoskeletal stability. MARK2 refers to MAP/microtubule affinity-regulating kinase 2 isoform a EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1 called MARK2. MARK3 was originally identified as a marker that was induced by treatment with DNA damaging agents, and loss of MARK3 was found with carcinogenesis in the pancreas. MARK4 contains an N terminal serine/threonine kinase domain, a central ubiquitin associated domain, and a C terminal KA1 associated kinase domain. RT PCR analysis detects upregulated expression of the gene for MARK4 in nearly all clinical hepatocellular carcinoma cells.
Specifications

Specifications

MARK3
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P27448
CTAK1, KP78, PAR1A, Par-1a, C-TAK1, ELKL motif kinase 2, EMK-2, cdc25C-associated protein kinase 1, protein kinase STK10, ser/Thr protein kinase PAR-1, serine/threonine-protein kinase p78
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
4140
Immunohistochemistry (Paraffin), Western Blot
OTI2D9
Unconjugated
MARK3
Liquid
MARK3
Human recombit protein fragment corresponding to amino acids 473-729 of MARK3 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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