MARK4 Mouse anti-Human, Clone: OTI9B7, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527002
DescriptionMARK1 (MAP/microtubule affinity-regulating kinase 1) belongs to the MARK family of serine/threonine kinases. MARK family protein kinases phosphorylate microtubule-associated proteins and may play a role in cytoskeletal stability. MARK2 refers to MAP/microtubule affinity-regulating kinase 2 isoform a EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1 called MARK2. MARK3 was originally identified as a marker that was induced by treatment with DNA damaging agents, and loss of MARK3 was found with carcinogenesis in the pancreas. MARK4 contains an N terminal serine/threonine kinase domain, a central ubiquitin associated domain, and a C terminal KA1 associated kinase domain. RT PCR analysis detects upregulated expression of the gene for MARK4 in nearly all clinical hepatocellular carcinoma cells.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|MARK4; MAP/microtubule affinity-regulating kinase 4; MARKL1; KIAA1860; Nbla00650; MARK4 serine/threonine protein kinase; MAP/microtubule affinity-regulating kinase like 1; FLJ90097; putative protein product of Nbla00650|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 390-467 of MARK4 produced in E.coli|
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