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MARK4 Mouse anti-Human, Clone: OTI9B7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527002

Catalog No. PIMA527002


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Description

Description

MARK1 (MAP/microtubule affinity-regulating kinase 1) belongs to the MARK family of serine/threonine kinases. MARK family protein kinases phosphorylate microtubule-associated proteins and may play a role in cytoskeletal stability. MARK2 refers to MAP/microtubule affinity-regulating kinase 2 isoform a EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1 called MARK2. MARK3 was originally identified as a marker that was induced by treatment with DNA damaging agents, and loss of MARK3 was found with carcinogenesis in the pancreas. MARK4 contains an N terminal serine/threonine kinase domain, a central ubiquitin associated domain, and a C terminal KA1 associated kinase domain. RT PCR analysis detects upregulated expression of the gene for MARK4 in nearly all clinical hepatocellular carcinoma cells.
Specifications

Specifications

MARK4
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q96L34
MARK4; MAP/microtubule affinity-regulating kinase 4; MARKL1; KIAA1860; Nbla00650; MARK4 serine/threonine protein kinase; MAP/microtubule affinity-regulating kinase like 1; FLJ90097; putative protein product of Nbla00650
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
57787
Immunohistochemistry (Paraffin), Western Blot
OTI9B7
Unconjugated
MARK4
Liquid
MARK4
Human recombit protein fragment corresponding to amino acids 390-467 of MARK4 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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