MASH1 Monoclonal Antibody (24B7.2D11.1), Active Motif™

Mouse Monoclonal Antibody

Supplier:  Active Motif 61272

Catalog No. 50-199-3290

Description

ASCL1 (also known as ASH1) is a basic helix-loop-helix transcription factor that is required for early development of the nervous system. Expressed in fetal brain, ASCL1 is essential for the proper development of autonomic neurons and for the survival of subsets of autonomic neurons. ASCL1 interaction with MEF-2A may regulate the expression of specific genes that are critical for the formation of distinct neuronal circuits within the central nervous system. The high level of ASCL1 expression in neuroendocrine tumors, such as medullary thyroid cancer, small cell lung cancer and lung cancer with neuroendocrine features may provide a useful marker for cancers with neuroendocrine features. Mapping to human chromosome 12, the ASCL1 gene contains a trinucleotide repeat region, making this locus a candidate for inherited disease.

Specifications

• Antigen: MASH1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
• Gene Accession No.: P19359, Q02067
• Gene Symbols: Ascl1
• Immunogen: This MASH1 antibody was raised against a full-length protein corresponding to rat MASH1.
• Quantity: 10 μg
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry, Western Blot
• Clone: 24B7.2D11.1
• Conjugate: Unconjugated
• Gene: Ascl1
• Gene Alias: achaete scute protein; achaete-scute complex homolog 1; achaete-scute complex homolog 1 (Drosophila); achaete-scute complex homolog-like 1; achaete-scute complex-like 1; achaete-scute complex-like protein 1; achaete-scute family bHLH transcription factor 1; Achaete-scute homolog 1; achaete-scute homolog 1-like; AI225900; ASCL1; ASH1; ASH-1; BHLHA46; Class A basic helix-loop-helix protein 46; HASH1; KMT2H; LOC100342114; mammalian achaete scute homolog 1; Mash1; Mash-1
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 17172, 64186
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid