MASTL Rabbit anti-Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA548683
DescriptionSerine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintece. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at ft.Ser-62 ft. and ft.Ser-67 ft., respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.
|PBS with 0.09% sodium azide|
|Serine/threonine-protein kinase greatwall, GW, GWL, Microtubule-associated serine/threonine-protein kinase-like, MAST-L, Mastl, Gw, Gwl|
|-20° C, Avoid Freeze/Thaw Cycles|
|KLH conjugated synthetic peptide between 561-589 amino acids from the Central region of mouse Mastl.|
|Antigen affinity chromatography|
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