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MASTL Rabbit anti-Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA548683

Catalog No. PA548683

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintece. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at  ft.Ser-62 ft. and  ft.Ser-67 ft., respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.
Specifications

Specifications

Mastl
Polyclonal
PBS with 0.09% sodium azide
Q8C0P0
Serine/threonine-protein kinase greatwall, GW, GWL, Microtubule-associated serine/threonine-protein kinase-like, MAST-L, Mastl, Gw, Gwl
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
67121
Western Blot
Unconjugated
Mastl
Liquid
MASTL
KLH conjugated synthetic peptide between 561-589 amino acids from the Central region of mouse Mastl.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Mouse
Documents
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