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MB67 Mouse anti-Human, Clone: OTI1B2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526713

Catalog No. PIMA526713


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Description

Description

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

MB67
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q14994
Nuclear receptor subfamily 1 group I member 3, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67, NR1I3, CAR
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
9970
Immunohistochemistry (Paraffin), Western Blot
OTI1B2
Unconjugated
NR1I3
Liquid
NR1I3
Human recombit protein fragment corresponding to amino acids 1-236 of NR1I3 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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