MBD1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Invitrogen 491027

Catalog No. 50-255-0798

Description

Methyl-CpG-binding domain protein 1 (MBD1) is a member of a family of mammalian proteins that specifically bind methylated regions of DNA. It is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). MBD1 acts as a transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.

Specifications

• Antigen: MBD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MBD1
• Gene Alias: CXXC3, CXXC-type zinc finger protein 3, Mbd1, methyl-CpG binding domain protein 1, methyl-CpG binding domain protein 1 isoform PCM1, methyl-CpG-binding domain protein 1, Methyl-CpG-binding protein MBD1, PCM1, Protein containing methyl-CpG-binding domain 1, RFT, the regulator of fibroblast growth factor 2 (FGF-2) transcription
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4152
• Content And Storage: -20°, C, Avoid Freeze/Thaw Cycles
• Isotype: IgG

• Applications: ChIP Assay, ELISA, Western Blot
• Concentration: 0.7 mg/mL
• Formulation: PBS with 0.1% BSA and 0.05% ProClin 300, 0.05% sodium azide
• Gene Accession No.: Q9UIS9
• Gene Symbols: MBD1
• Immunogen: Raised against the human MBD1 protein.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid