MBD1 Mouse anti-Human, Clone: OTI2H5, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527525
DescriptionMethyl-CpG-binding domain protein 1 (MBD1) is a member of a family of mammalian proteins that specifically bind methylated regions of DNA. It is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). MBD1 acts as a transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Isoform 1 and isoform 2 can also repress transcription form unmethylated promoters.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Methyl CpG Binding Domain Protein 1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 222-556 of MBD1 produced in E.coli|
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