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MBP Mouse anti-Human, Clone: V/h5, Abnova™

Mouse monoclonal antibody raised against human MBP.

Manufacturer:  Abnova Corporation MAB12574

Catalog No. 89-934-522


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Description

Description

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called “Golli-MBP”) that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq]

Specifications

Specifications

MBP
V/h5
Mouse monoclonal antibody raised against human MBP.
In PBS (0.09% sodium azide).
MGC99675
Mouse
IgG1
50 ug
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Monoclonal
Human
ELISA, Immunohistochemistry (PFA fixed), Radioimmune Assays
Unconjugated
ELISA Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/mL) Radioimmunoassay The optimal working dilution should be determined by the end user.
Liquid
MBP
A fragment (conjugated with BSA) corresponding to amino acids 1-118 at N-terminus of human MBP.
Protein A purification
RUO
Primary
4155
SDS
Documents
Product Certifications
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