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MBP Mouse anti-Mouse, Rat, Clone: GT3412, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527818

Catalog No. PIMA527818


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Description

Description

Positive Control: mouse brain Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the  ft.shiverer ft. and  ft.myelin deficient ft. phenotypes in mouse.
Specifications

Specifications

MBP
Monoclonal
0.1 mg/mL
PBS with no preservative
P02688, P04370
C76307, Hmbpr, Mbp, Myelin basic Protein, R75289, golli mbp, mld, shi
Mouse
IgG1
100 μl
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
17196, 24547
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
GT3412
Unconjugated
Mbp
Liquid
Mbp
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of mouse Myelin basic Protein. The exact sequence is proprietary.
Protein G
RUO
Antibody
Monoclonal
Mouse, Rat
Documents
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