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MBP Rabbit anti-Mouse, Rat, Unconjugated, Clone: ARC0535, Invitrogen™

Rabbit Monoclonal Antibody

Manufacturer:  Invitrogen MA535074

Catalog No. PIMA535074


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Description

Description

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
Specifications

Specifications

MBP
ARC0535
PBS with 50% glycerol and 0.2% sodium azide; pH 7.3
P02688, P04370
BOS_22097; C76307; golli mbp; golli-mbp; Hmbpr; MBP; Mbps; MGC99675; mld; Myelin A1 protein; Myelin basic protein; Myelin membrane encephalitogenic protein; R75289; Shi
Rabbit
IgG
100 μL
-20°C, Avoid Freeze/Thaw Cycles
Primary
17196, 24547
Immunofluorescence, Immunohistochemistry, Western Blot
Unconjugated
MBP
Liquid
MBP
A synthesized peptide derived from human Myelin Basic Protein
Protein A
RUO
Antibody
Monoclonal
Mouse, Rat
SDS
Documents
Product Certifications
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