Invitrogen™ MC1R Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5102106

Catalog No. PIPA5102106

Description

Antibody detects endogenous levels of total MSHR.

MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). MSH and its receptor, MC1R, are key regulators of melanogenesis. They control the relative proportions of red pheomelanin and black photoprotective eumelanin in the skin by increasing the production of eumelanin. Non-functional, truncated forms of the receptor lead to lighter coat color in animals. In contrast, constitutively active receptors lead to darker color.

Specifications

• Antigen: MC1R
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mc1r
• Gene Alias: alpha melanocyte stimulating hormone receptor; CMM5; e; extension recessive yellow; MC1 receptor; MC1R; MC1-R; melanocortin 1 receptor; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); melanocortin receptor 1; melanocortin-1 receptor; melanocyte-stimulating hormone receptor; melanotropin receptor; MSHR; MSH-R; Mshra; SHEP2; Tob; tobacco darkening
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 102552838, 17199, 4157
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q01726, Q01727
• Gene Symbols: Mc1r
• Immunogen: A synthesized peptide derived from human MC1R(Accession Q01726), corresponding to amino acid residues N279-W317.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG