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PCBP4 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550704

Catalog No. PA550704


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Description

Description

The antibody detects endogenous levels of total MCG10 protein.

MCG10 is a member of the KH-domain RNA-binding protein family. Proteins of this family also referred to as alpha-CPs, bind to RNA with specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. MCG10 is induced by p53 and DNA damage via two p53-responsive promoter elements. Its overexpression in transfected cells results in the suppression of cell proliferation by inducing apoptosis and cell cycle arrest in G2-M. Decreased expression of one isoform of MCG10 has been observed in many forms of lung cancer, leading to speculation that MCG10 can act as a tumor suppressor. Multiple alternatively spliced isoforms of MCG10 have been identified.
Specifications

Specifications

PCBP4
Polyclonal
Unconjugated
PCBP4
Liquid
PCBP4
Synthetic peptide corresponding to residues near the C terminal of human poly(rC) binding protein 4
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
1.9 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
P57723, P57724
CBP, LIP4, MCG10
Rabbit
IgG
100 μL
-20°C
Primary
57060, 59092
Documents
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