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Thermo Scientific™ Lab Vision™ Mcl-1 Ab-1, Mouse Monoclonal Antibody

Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ Mcl-1 Ab-1, Mouse Monoclonal Antibody.

Specifications

Antigen Mcl-1 Ab-1
Clone RC13
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Format Concentrated
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Products 2
Catalog Number Mfr. No. Concentration Conjugate Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Concentration Conjugate Quantity Price Quantity & Availability  
MS681P0
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Thermo Scientific™
MS681P0
400ug/mL Unconjugated 100μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
MS681PABX
View Documents
Thermo Scientific™
MS681PABX
1mg/mL Unconjugated 200μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
Description

Description

Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ Mcl-1 Ab-1, Mouse Monoclonal Antibody.

Mcl-1 (Myeloid cell leukemia-1) is a member of the bcl-2 family. The carboxy terminal of Mcl-1 and bcl-2 share significant sequence homology. Expression of Mcl-1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g. ionizing radiation, ultraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in bcl-2. Enhanced expression of Mcl-1, prominently associated with mitochondria, complements the continued expression of bcl-2 in ML-1 cells undergoing differentiation. Like bcl-2, Mcl-1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis.

Host Species: Mouse

Clone: RC13

Isotype: IgG1/κ

Species Reactivity: Human. Others not known.

Epitope: aa 1-327

Immunogen: Recombinant human Mcl-1 protein corresponding to aa 1-327

Molecular Weight: 42kDa

Positive Control: Raji cells, Spleen or tonsil

Cellular Localization: Predominantly nuclear; occasionally cytoplasmic

Recommended for:

  • Western Blotting
  • Immunoprecipitation (Denatured verified)

Note:

USA: RUO; Int'l: RUO

Specifications

Specifications

Mcl-1 Ab-1
Immunoprecipitation, Western Blot
Concentrated
RUO
Primary
IgG2a kappa
RC13
Monoclonal
Murine
Apoptosis
Recombinant human Mcl-1 protein corresponding to aa 1-327
SDS
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