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MCL-1 Mouse anti-Human, Mouse, Clone: LVUBKM, eBioscience™ Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

$1200.00 - $3000.00

Specifications

Antigen MCL-1
Clone LVUBKM
Concentration 0.5 mg/mL
Applications Flow Cytometry, Immunohistochemistry (Paraffin)
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
14-904-795 Non-distribution product as customer accommodation.
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N/A 10 mg
Each for $3,000.00
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14-904-737 Non-distribution product as customer accommodation.
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N/A 2 mg
Each for $1,200.00
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Description

Description

This LVUBKM MAb recognizes human and mouse myeloid cell leukemia sequence 1 (Mcl-1). Mcl-1 is an anti-apoptotic member of the Bcl-2 family of proteins important for regulation of cell survival/apoptosis. Mcl-1 is primarily localized to the outer membrane of mitochondria where it prevents cytochrome c release via dimerization with other Bcl-2 family members such as Bim. Although it is expressed in both immune and non-immune cells, highest levels of Mcl-1 expression are seen in hematopoietic lineage cells. PI3K activation of AKT results in destabilization and degradation of GSK3 beta, which prevents phosphorylation of Mcl-1 on S159 and its subsequent ubiquitnation and degradation. Mice conditionally lacking Mcl-1 in lymphocytes showed that Mcl-1 is essential during early lymphoid development and for the maintenance of mature lymphocytes.

MCL-1 Monoclonal antibody specifically detects MCL-1 in Human, Mouse samples. It is validated for Flow Cytometry, Immunohistochemistry (Paraffin)
Specifications

Specifications

MCL-1
0.5 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
AW556805; BCL2 family apoptosis regulator; BCL2L3; bcl2-L-3; Bcl-2-like protein 3; Bcl-2-related protein EAT/mcl1; EAT; Induced myeloid leukemia cell differentiation protein Mcl-1; induced myeloid leukemia cell differentiation protein Mcl-1 homolog; MCL1; Mcl-1; mcl1/EAT; MCL1-ES; MCL1L; MCL1S; MCL-1S; MGC104264; MGC1839; myeloid cell leukemia 1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1; myeloid cell leukemia sequence 1 (BCL2-related); TM
IgG1, kappa
Primary
4° C
MCL1
LVUBKM
Flow Cytometry, Immunohistochemistry (Paraffin)
Unconjugated
Mouse
Human, Mouse
P97287, Q07820
17210, 4170
Monoclonal
Affinity chromatography
Antibody
SDS
Product Certifications
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