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MCL-1 Monoclonal Antibody (LVUBKM), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

$162.00 - $1372.00

Specifications

Antigen MCL-1
Clone LVUBKM
Concentration 0.5 mg/mL
Applications Flow Cytometry, Immunohistochemistry (Paraffin)
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
14-904-737
Encompass_Preferred
View Documents
LIFE TECHNOLOGIES
14904737
2 mg
Each for $1,372.00
Add to Cart
 
14-904-780
Encompass_Preferred
View Documents
LIFE TECHNOLOGIES
14904780
25 μg
Each for $162.00
Add to Cart
 
Description

Description

This LVUBKM MAb recognizes human and mouse myeloid cell leukemia sequence 1 (Mcl-1). Mcl-1 is an anti-apoptotic member of the Bcl-2 family of proteins important for regulation of cell survival/apoptosis. Mcl-1 is primarily localized to the outer membrane of mitochondria where it prevents cytochrome c release via dimerization with other Bcl-2 family members such as Bim. Although it is expressed in both immune and non-immune cells, highest levels of Mcl-1 expression are seen in hematopoietic lineage cells. PI3K activation of AKT results in destabilization and degradation of GSK3 beta, which prevents phosphorylation of Mcl-1 on S159 and its subsequent ubiquitnation and degradation. Mice conditionally lacking Mcl-1 in lymphocytes showed that Mcl-1 is essential during early lymphoid development and for the maintenance of mature lymphocytes.

MCL1 (Myeloid cell leukemia-1) belongs to the Bcl-2 family and is involved in programing, differentiation and concomitant maintenance of cell viability, but not of proliferation. Isoform 1 of MCL1 inhibits apoptosis while isoform 2 promotes it. The carboxy terminal of MCL1 and bcl-2 share significant sequence homology. Expression of MCL1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g. ionizing radiation, μgtraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in bcl-2. Enhanced expression of MCL1, prominently associated with mitochondria, complements the continued expression of bcl-2 in ML-1 cells undergoing differentiation. Like bcl-2, MCL1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis. While the mechanism by which MCL1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. MCL1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. MCL1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals. MCL1 exists as at least two distinct isoforms designated MCL1L and MCL1S. In marked contrast to the larger isoform of MCL1, overexpression of MCL1S promotes cell death.
Specifications

Specifications

MCL-1
0.5 mg/mL
Monoclonal
Liquid
RUO
P97287, Q07820
IgG1 κ
Affinity chromatography
MCL1
LVUBKM
Flow Cytometry, Immunohistochemistry (Paraffin)
Unconjugated
Mouse
Human, Mouse
17210, 4170
Primary
Antibody
SDS
Documents

Documents

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