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MCM7 Rabbit anti-Human, Rat, Unconjugated, Clone: ARC0573, Invitrogen™

Rabbit Monoclonal Antibody

Manufacturer:  Invitrogen MA535097

Catalog No. PIMA535097


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Description

Description

MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Specifications

Specifications

MCM7
ARC0573
PBS with 50% glycerol and 0.2% sodium azide; pH 7.3
P33993
AI747533; BOS_23012; Cdc47; CDC47 homolog; CDC47 homolog A; CDC47p; DNA replication licensing factor MCM7; DNA replication licensing factor mcm7-A; mCDC47; MCM2; Mcm7; mcm7-a; mcm7-b; Mcmd7; Minichromosome maintenance protein 7-A; P1 P85MCM; P1.1-MCM3; P1CDC47; P85MCM; p90; PNAS146; PPP1R104; XELAEV_18000877mg; xMCM7-A
Rabbit
IgG
100 μL
-20°C, Avoid Freeze/Thaw Cycles
Primary
288532, 4176
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
Unconjugated
Mcm7
Liquid
Mcm7
A synthesized peptide derived from human MCM7
Protein A
RUO
Antibody
Monoclonal
Human, Rat
SDS
Documents
Product Certifications
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