Invitrogen™ MCMBP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA558410

Catalog No. PIPA558410

Description

Immunogen sequence: SPRNTTLERQ TFYCVPVPGE STWVKEAYVN ANQARVSPST SYTPSRHKRS YEDDDDMDLQ PNKQKDQHAG ARQAGSVGGL QWCGEPKRLE TEASTGQ Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 90%.

MEK1 (Mitogen activated protein kinase kinase 1) catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEK1 activates ERK1 and ERK2 MAP kinases. Mitogen activated protein kinase kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1.

Specifications

• Antigen: MCMBP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MCMBP
• Gene Alias: 1110007A13Rik; AU017382; BC025641; C10orf119; cj119; MCM (minichromosome maintenance deficient) binding protein; MCM-binding protein; Mcmbp; MCM-BP; minichromosome maintenance complex binding protein; Mini-chromosome maintenance complex-binding protein; minichromosome maintenance complex-binding protein; RGD1306730
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 210711, 309009, 79892
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: B1H268, Q8R3C0, Q9BTE3
• Gene Symbols: MCMBP
• Immunogen: Recombinant protein corresponding to Human MCMBP. Recombinant protein control fragment (Product #RP-97206).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG