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Tocris™ (±)-McN 5652

Potent, orally active 5-HT uptake inhibitor. Also inhibits noradrenalin and dopamine uptake in vitro

Manufacturer:  Tocris™ 2148/10

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Catalog No. 21-481-0R


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For Research Use Only


Specifications

Description

Potent, high affinity serotonin re-uptake inhibitor; selective in vivo. Displays moderate selectivity over noradrenalin and dopamine re-uptake in vitro (Ki values are 0.68, 2.9 and 36.8nM for inhibition of serotonin, noradrenalin and dopamine uptake respectively in rat brain synaptosomes). Potently potentiates 5-HT-induced effects in vivo following oral administration. Biological activity resides predominantly in the (+)-enantiomer.
  • Chemical Name: (6R,10bS)-rel-1,2,3,5,6,10b-Hexahydro-6-[4-(methylthio)phenyl]-pyrrolo[2,1-a]isoquinoline
  • Formula: C19H21NS
  • CAS Number: 96795-89-0
  • Solubility: Soluble to 50mM in 1eq. HCl and to 75mM in DMSO
Description & Specifications

Specifications

(±)-McN 5652
>95
10mg
(±)-McN 5652
295.44
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