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MCPH1 Mouse anti-Human, Clone: OTI2A3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526706

Catalog No. PIMA526706


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Description

Description

Microcephalin (MCPH1, BRCT-repeat inhibitor of TERT expression 1, BRIT1) modulates brain size and has been proliferating under strong positive selection for several thousand years, although the nature of the positive selection is poorly understood. Human Microcephalin contains three BRCA1 C-terminal (BRCT) domains and shares 57% identity with its mouse ortholog, the most conserved regions being BRCT domains where there is 80% identity. Predomit expression of human Microcephalin is observed in fetal brain, liver and kidney tissues and is expressed during neurogenesis in mice. Microcephalin displays significantly higher rates of protein evolution in primates than in rodents; this trend is most noticeable for the subset of genes associated with nervous system development. Microcephalin has a very young, single nucleotide, polymorphism haplotype associated with modern humans; this gene is presumably still evolving in Homo sapiens. It functions in DNA damage response and regulation of cell cycle checkpoints.
Specifications

Specifications

MCPH1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q8NEM0
BRCT repeat inhibitor of TERT expression 1; BRIT 1; FLJ12847; Hypothetical protein FLJ12847; MCPH 1; MCPH1; MCPH1; MCT; Microcephalin 1; Microcephalin; Microcephaly primary autosomal recessive 1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
79648
Immunohistochemistry (Paraffin), Western Blot
OTI2A3
Unconjugated
MCPH1
Liquid
MCPH1
Human recombit protein fragment corresponding to amino acids 1-264 of MCPH1 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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