MDC1 Mouse anti-Bovine, Human, Mouse, Clone: P2B11, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527650
DescriptionThe protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
|PBS with 50% glycerol and 0.09% sodium azide; pH 7.4|
|Nuclear factor with BRCT domains1, mediator of DNA damage checkpoint 1|
|-20° C, Avoid Freeze/Thaw Cycles|
|240087, 511168, 9656|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|GST-tagged recombit protein corresponding to mouse MDC1 at and around the N-terminus|
|Bovine, Human, Mouse|
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