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MDC1 Mouse anti-Bovine, Human, Mouse, Clone: P2B11, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527650

Catalog No. PIMA527650


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Description

Description

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Specifications

Specifications

MDC1
Monoclonal
1 mg/ml
PBS with 50% glycerol and 0.09% sodium azide; pH 7.4
Q14676, Q5PSV9
Nuclear factor with BRCT domains1, mediator of DNA damage checkpoint 1
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
240087, 511168, 9656
Immunocytochemistry, Immunofluorescence, Western Blot
P2B11
Unconjugated
MDC1
Liquid
Mdc1
GST-tagged recombit protein corresponding to mouse MDC1 at and around the N-terminus
Protein G
RUO
Antibody
Monoclonal
Bovine, Human, Mouse
Documents
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