MDMX Mouse anti-Human, Clone: OTI4G5, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526198
DescriptionThis gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter ft.s degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|RP11-430C7.1, DKFZp781B1423, HDMX, MDMX, MGC132766, MRP1, MDM4-related protein 1; Mdm4, transformed 3T3 cell double minute 4, p53 binding protein; double minute 4 homolog; double minute 4 protein; double minute 4, human homolog of; p53-binding protein; mdm2-like p53-binding protein; p53-binding protein Mdm4; protein Mdm4; protein Mdmx|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of MDM4 produced in HEK293T cell|
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