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MED12 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549863

Catalog No. PA549863


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Description

Description

The antibody detects endogenous levels of total MED12 / TRAP230 protein.

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009].
Specifications

Specifications

MED12
Polyclonal
Unconjugated
MED12
Liquid
MED12
Synthesized peptide derived from internal of human MED12.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q93074
Thyroid hormone receptor-associated protein complex 230 kDa component, Trap230, Activator-recruited cofactor 240 kDa component, ARC240, CAG repeat protein 45
Rabbit
IgG
100 μL
-20°C
Primary
9968
Documents
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