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Phospho-MEK1/MEK2 (Ser221) Rabbit anti-Human, Mouse, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer:  Invitrogen MA528038

Catalog No. PIMA528038


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Description

Description

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using Recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

MEK1 (Mitogen activated protein kinase 1) catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEK1 activates ERK1 and ERK2 MAP kinases. Mitogen activated protein kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1.
Specifications

Specifications

Phospho-MEK1/MEK2 (Ser221)
Recombinant Monoclonal
0.5 mg/ml
PBS with 0.1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
P31938, P36507, Q02750, Q63932
MAP2K1, MAP2K2
A synthetic phospho-peptide corresponding to residues surrounding Ser221 of human phospho MEK1/2
Protein A/G
RUO
Antibody
Monoclonal
Human, Mouse
Flow Cytometry, Western Blot
MEK12S221-D3
Unconjugated
MAP2K2
Liquid
Rabbit
IgG1, kappa
200 μl
-20°C
Primary
26395, 26396, 5604, 5605
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