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MEK3 Rabbit anti-Human, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer:  Invitrogen 702225

Catalog No. PI702225


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Description

Description

This antibody is predicted to react with Monkey, Dog, Cat, Mouse Recombit rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombit rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

MKK3 (MEK3) is a dual specificity protein kinase that belongs to the MAP kinase kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
Specifications

Specifications

MEK3
Recombinant Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.4
P46734
MEK3, MKK3, PRKMK3, SKK2
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
5606
Immunocytochemistry, Western Blot
1H8L14
Unconjugated
MAP2K3
Liquid
MAP2K3
Peptides corresponding to human MEK3 (a.a.16-28, 329-346)
Protein A
RUO
Antibody
Monoclonal
Human
Documents
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