Melanoma Marker Mouse anti-Human, Alexa Fluor™ 594, Clone: M2-7C10 + M2-9E3 + T311 + HMB45, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP234681AF594

Catalog No. NP234681A94

Description

Melanoma Marker (MART-1 + Tyrosinase + gp100) Monoclonal antibody specifically detects Melanoma Marker (MART-1 + Tyrosinase + gp100) in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen).

Specifications

• Antigen: Melanoma Marker (MART-1 + Tyrosinase + gp100)
• Clone: M2-7C10 + M2-9E3 + T311 + HMB45
• Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
• Format: Conjugated, Purified
• Host Species: Mouse
• Isotype: IgG2b/IgG2a/IgG1
• Quantity: 0.1 mL
• Primary or Secondary: Primary
• Gene ID (Entrez): 2315.0
• Target Species: Human

• Applications: Immunohistochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
• Conjugate: Alexa Fluor™ 594
• Formulation: 50 mM sodium borate with 0.05% sodium azide
• Gene Alias: MART1, MART-1, melan-A, MLANA
• Immunogen: Recombinant hMART-1 protein (M2-7C10; M2-9E3); Recombinant tyrosinase protein (T311); Extract of pigmented melanoma metastases from lymph nodes (HMB45)
• Purification Method: Protein A purified
• Storage Requirements: Store at 4°C in the dark.
• Monoclonal or Polyclonal: Monoclonal
• Test Specificity: This antibody cocktail recognizes three melanoma-specific proteins, which include MART-1, Tyrosinase and gp100. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Function of gp100 is not known but it is reported to be a useful marker for melanocytes and melanomas. This cocktail of three markers is designed for extremely sensitive labeling of formalin-fixed, paraffin-embedded melanomas and other tumors showing melanocytic differentiation.