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MERS Coronavirus Spike Protein S1 Mouse anti-Virus, Clone: 3871, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA533278

Catalog No. PIMA533278


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Description

Description

The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell: they are essential for both host specificity and viral infectivity. The term ′peplomer′ is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV.
Specifications

Specifications

MERS Coronavirus Spike Protein S1
Monoclonal
100 μg/mL
PBS with 0.1% sodium azide; pH 7.2
Mouse
Protein A
RUO
Antibody
Monoclonal
ELISA, Immunocytochemistry, Immunofluorescence
3871
Unconjugated
Liquid
IgG1
1 mL
4° C
Primary
Virus
SDS
Documents
Product Certifications
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