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MERTK Rabbit anti-Human, Rat, Unconjugated, Clone: ARC0229, Invitrogen™

Rabbit Monoclonal Antibody

Manufacturer:  Invitrogen MA535159

Catalog No. PIMA535159


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Description

Description

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Specifications

Specifications

MERTK
ARC0229
PBS with 50% glycerol and 0.2% sodium azide; pH 7.3
P57097, Q12866
c-Eyk; c-mer; Eyk; MER; Mertk; MGC133349; nmf12; Nyk; Proto-oncogene c-Mer; rdy; Receptor tyrosine kinase MerTK; RP38; sMER; sMERTK; soluble MER; soluble MERTK; Tyro 12; Tyro12; Tyrosine-protein kinase Mer
Rabbit
IgG
100 μL
-20°C, Avoid Freeze/Thaw Cycles
Primary
10461, 65037
Western Blot
Unconjugated
Mertk
Liquid
Mertk
A synthesized peptide derived from human MERTK
Protein A
RUO
Antibody
Monoclonal
Human, Rat
SDS
Documents
Product Certifications
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