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MET Mouse anti-Human, Clone: OTI18A5, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF804960

Catalog No. 50-166-7237


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

MET is a tyrosine kinase receptor for the hepatocyte growth factor. It is linked to functions such as cell proliferation, scattering, morphogenesis, and survival. Ligand binding at the cell surface induces autophosphorylation of MET that provides docking sites for downstream signaling molecules. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
Specifications

Specifications

MET
Monoclonal
Unconjugated
MET
Lyophilized
MET
Human recombit protein fragment corresponding to amino acids 125-421 of human MET produced in E.coli.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Western Blot
OTI18A5
PBS with 8% trehalose and no preservative; pH 7.3
P08581
AUTS9, DFNB97, HGFR, RCCP2, c-Met
Mouse
IgG2a
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
4233
SDS
Documents
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