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  7. Mevastatin, 98%, Thermo Scientific Chemicals

Mevastatin, 98%, Thermo Scientific Chemicals

Catalog Number aaj61357lb0
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Quantity:
5 mg
10 mg
25 mg
73573-88-3
C23H34O5
390.52
MFCD05662341
AJLFOPYRIVGYMJ-INTXDZFKSA-N
mevastatin, compactin, mevastatinum, mevastatina, mevastatine, mevastatinum inn-latin, antibiotic ml 236b, mevastatin inn, compactin penicillium, mevastatine inn-french
64715
CHEBI:34848
[(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12
73573-88-3
C23H34O5
390.52
MFCD05662341
AJLFOPYRIVGYMJ-INTXDZFKSA-N
mevastatin, compactin, mevastatinum, mevastatina, mevastatine, mevastatinum inn-latin, antibiotic ml 236b, mevastatin inn, compactin penicillium, mevastatine inn-french
64715
CHEBI:34848
[(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12

Description

Mevastatin (Compactin) inhibits HMGCR (HMG-CoA reductase) , induces apoptosis which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Mevastatin causes cells to arrest early in the G1 phase. Mevastatin is a close structural analog of lovastatin and both agents have the same biochemical and pharmacological activities. Mevastatin is inactive in cell-free assays. In cells however, it is hydrolyzed to the active free acid form by intracellular esterases.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Mevastatin (Compactin) inhibits HMGCR (HMG-CoA reductase) , induces apoptosis which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Mevastatin causes cells to arrest early in the G1 phase. Mevastatin is a close structural analog of lovastatin and both agents have the same biochemical and pharmacological activities. Mevastatin is inactive in cell-free assays. In cells however, it is hydrolyzed to the active free acid form by intracellular esterases.

Solubility
Soluble in ethanol at 25 mg/mL and in DMSO at 20mg/ml

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C
TRUSTED_SUSTAINABILITY
Color White
Quantity 5 mg
Beilstein 1269441
Merck Index 14,6164
Solubility Information Soluble in ethanol at 25 mg/mL and in DMSO at 20mg/ml
Formula Weight 390.52
Percent Purity 98%
Physical Form Crystalline Solid
Chemical Name or Material Mevastatin

Safety and Handling

RTECSNumber EK7907100
TSCA No
Recommended Storage Keep cold
SDS

RUO – Research Use Only

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