MFN1 Mouse anti-Human, Clone: OTI2E4, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF802196

Catalog No. 50-166-5900

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

MFN1 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development. When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane.

Specifications

• Antigen: MFN1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: MFN1
• Gene Alias: hfzo1, hfzo2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55669
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI2E4
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q8IWA4
• Gene Symbols: MFN1
• Immunogen: Human recombit protein fragment corresponding to amino acids 209-469 of human MFN1 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1