MFN1 Mouse anti-Human, Clone: OTI4H4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526526
DescriptionMitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development. When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|hfzo1, hfzo2, Mitofusin-1, Fzo homolog|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 209-469 of MFN1 produced in E.coli|
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