Invitrogen™ MFSD2A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5107175

Catalog No. PIPA5107175

Description

Sequence homology: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 86%; Rat: 93%; Zebrafish: 93%.

Multidrug transporters, such as MFSD2A, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. Major Facilitator Superfamily (MFS) members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment and has recently been described as the human receptor for syncytin-2, a retrovirus-derived protein mediating fusion of placental trophoblasts. MFSD2A is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting. The activation of the betaAR signaling pathway plays a major role in the induction of MFSD2A expression during adaptive thermogenesis.

Specifications

• Antigen: MFSD2A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MFSD2A
• Gene Alias: 1700018O18Rik; HMFN0656; major facilitator superfamily domain containing 2; major facilitator superfamily domain containing 2A; major facilitator superfamily domain-containing protein 2A; MCPH15; MFSD2; MFSD2A; NLS1; PP9177; RGD1310174; sodium-dependent LPC symporter 1; sodium-dependent lysophosphatidylcholine symporter 1; UNQ300/PRO341; zgc:101615
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84879
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q8NA29
• Gene Symbols: MFSD2A
• Immunogen: Synthetic peptide directed towards the N-terminal region of human MFSD2A.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG