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mGluR8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550507

Catalog No. PA550507


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Description

Description

The antibody detects endogenous levels of total mGluR8 protein.

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Specifications

Specifications

mGluR8
Polyclonal
Unconjugated
GRM8
Liquid
GRM8
Synthetic peptide corresponding to a region derived from internal residues of human glutamate receptor, metabotropic 8
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunohistochemistry (Paraffin), Western Blot
2.4 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
O00222, P47743, P70579
FLJ41058, GLUR8, GPRC1H, MGC126724, MGLUR8, mGlu8
Rabbit
IgG
100 μL
-20°C
Primary
14823, 2918, 60590
Documents
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