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  6. Thermo Scientific Chemicals MIF Antagonist, ISO-1

Thermo Scientific Chemicals MIF Antagonist, ISO-1

Catalog Number aaj64947mb
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Quantity:
5 mg
25 mg
478336-92-4
C12H13NO4, C12H13NO4
(S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester; Macrophage Migration Inhibitory Factor Antagonist
478336-92-4
C12H13NO4, C12H13NO4
(S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester; Macrophage Migration Inhibitory Factor Antagonist

Description

A cell-permeable isoxazoline compound

MIF Antagonist, ISO-1 inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC50 = 7 μM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes and arachidonic acid in RAW 264.7 macrophages. MIF Antagonist, ISO-1 has been shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

TRUSTED_SUSTAINABILITY
Quantity 25 mg
Description Pale Yellow
Content And Storage -30°C to -10°C
For Use With (Application) A cell-permeable isoxazoline compound
Formula Weight 235.24g/mol
Sensitivity Light Sensitive
Product Type Signal Transduction Reagent
Form Solid
InChI Key CLVQGFPQFNASJH-UHFFFAOYNA-N
SMILES COC(=O)CC1CC(NO1)=C1C=CC(=O)C=C1
IUPAC Name methyl 2-[3-(4-oxocyclohexa-2,5-dien-1-ylidene)-1,2-oxazolidin-5-yl]acetate
Molecular Weight (g/mol) 235.24
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Safety and Handling

Recommended Storage Store at -20°C; Store under Argon
SDS

RUO – Research Use Only

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