MKL2 Mouse anti-Human, Clone: CL1546, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524628
Immunogen sequence: QRPGPMELVE KNILPVDSSV KEAIIGVGKE DYPHTQGDFS FDEDSSDALS PDQPASQESQ GSAASPSEPK VSESPSPVTT NTPAQFASVS PTVPEFLKTP PTADQPPPRP AAPVLPTNTV SSAKPGPALV KQSHPKNP Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 54%. Binds to an epitope located within the peptide sequence FASVSPTVPEFLKTP as determined by overlapping synthetic peptides.Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF regulates the transient response of several muscle genes in response to growth factors and recruits accessory myogenic factors to activate these muscle genes. SRF is required for the formation of vertebrate mesoderm leading to the origin of the cardiovascular system. Myocardin, in association with SRF in cardiac muscle cells, activates cardiac muscle promoters. Myocardin-related transcription factors A and B (MRTF-A and MRTF-B) interact with SRF and act as stimulators for its transcriptional activity. MRTF-B is crucial for skeletal myogenic differentiation.
|PBS with 40% glycerol and 0.02% sodium azide; pH 7.2|
|MKL/myocardin-like protein 2, Megakaryoblastic leukemia 2, Myocardin-related transcription factor B, MRTF-B, MKL2, KIAA1243, MRTFB|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Recombit protein corresponding to Human MKL2|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok
Research Use Only