MKP3 Rabbit anti-Human, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA549608
DescriptionDUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Twotranscript variants encoding different isoforms have been found for the DUSP6 gene.
|PBS with 0.09% sodium azide|
|Dual specificity protein phosphatase 6, Mitogen-activated protein kinase phosphatase 3, MAP kinase phosphatase 3, MKP-3, Dusp6, Mkp3|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Western Blot|
|6xHIS-tagged recombit protein encoding aa 1∽381 of rat MKP3.|
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