Tocris™ ML 154

Potent neuropeptide S receptor (NPSR) antagonist

Manufacturer: Tocris™ 5161/50

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Catalog No. 51-615-0

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For Research Use Only


    Inhibitors ML 154
    Purity >99
    Molecular Weight 545.47
    Quantity 50mg
    Product Type ML 154

    Potent neuropeptide S receptor (NPSR) antagonist (pA2 = 9.98). Inhibits neuropeptide S-induced ERK phosphorylation over cAMP responses and calcium responses (IC50 values are 9.3, 22.1 and 36.5 nM, respectively). Appears to modulate addictive behavior in vivo. Displays no activity against vasopressin V1B receptors. Brain penetrant.

    • Chemical Name: 3-(Diphenylphosphinothioyl)-2-methyl-1-[(2E)-3-phenyl-2-propen-1-yl]imidazo[1,2-a]pyridinium bromide
    • Formula: C29H26N2PS.Br
    • CAS Number: 1345964-89-7
    • Solubility: Soluble to 100mM in DMSO and to 50mM in ethanol
    • Purity: >99

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