Tocris ML 277
Selective Kv7.1 (KCNQ1) potassium channel activator; augments IKs current
Manufacturer: Tocris 4777/10
DescriptionSelective Kv7.1 (KCNQ1) potassium channel activator (EC50 = 260nM). Exhibits >100-fold selectivity versus KCNQ2, KCNQ4 and hERG potassium channels. Augments IKs current of cultured human cardiomyocytes and shortens action potential duration.
- Chemical Name: (2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide
- Formula: C23H25N3O4S2
- CAS Number: 1401242-74-7
- Solubility: Soluble to 100mM in DMSO
- Purity: >98
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