Selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). Exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters. Prevents PTZ-induced epileptic seizures in mice. Brain penetrant.
Chemical Name: N-(3,4-Difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea
CAS Number: 1443246-62-5
Solubility: Soluble to 100mM in DMSO and to 50mM in ethanol
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