MLF1 Mouse anti-Human, Clone: OTI2D6, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525976
DescriptionMLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. The protein interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. It suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Myeloid leukemia factor 1; Myelodysplasia-myeloid leukemia factor 1; MLF-1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of MLF1 produced in E.coli|
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