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MLN51/CASC3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 180471AP

Catalog No. 50-173-1958


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Description

Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Two transcript variants encoding different isoforms have been identified.
Specifications

Specifications

MLN51/CASC3
0.33 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O15234, Q8K3W3, Q8K3X0
BTZ, CASC3, MLN 51, MLN51, Protein barentsz, Protein CASC3
Rabbit
IgG
150 μL
-20°C
Primary
192160, 22794, 259170
Immunocytochemistry, Immunofluorescence, Western Blot
Unconjugated
CASC3
Liquid
Casc3
MLN51/CASC3 Fusion Protein Ag12694
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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