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MMP-1 Mouse anti-Human, Clone: 36665R, R&D Systems™

Recombinant Monoclonal Antibody

$148.35 - $369.00

Specifications

Antigen MMP-1
Formulation Supplied as a solution in PBS. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with No Preservative
Format Purified
Clone 36665R
Applications Immunohistochemistry, KnockDown, Western Blot
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
MAB901R100 View Documents R&D Systems
MAB901R100
100 ug Each for $369.00
Add to cart
 
MAB901RSP View Documents R&D Systems
MAB901RSP
25 ug Each for $148.35
Add to cart
 
Description

Description

Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-1 (interstitial collagenase), can degrade a broad range of substrates including types I, II, III, VII, VIII, and X collagens as well as casein, gelatin, α-1 antitrypsin, myelin basic protein, L-Selectin, pro-TNF, IL-1β, IGF-BP3, IGF-BP5, pro MMP-2 and pro MMP-9. A significant role of MMP-1 is the degradation of fibrillar collagens in extracellular matrix remodeling, characterized by the cleavage of the interstitial collagen triple helix into 3/4, 1/4 fragments. However, as the list of substrates above illustrates, the role of MMP-1 is more diverse than originally envisaged, and may involve enzyme cascades, cytokine regulation and cell surface molecule modulation. MMP-1 is expressed by fibroblasts, keratinocytes, endothelial cells, monocytes and macrophages. Structurally, MMP-1 may be divided into several distinct domains; a pro-domain which is cleaved upon activation; a catalytic domain containing the zinc binding site; a short hinge region and a carboxyl terminal (hemopexin-like) domain.
Specifications

Specifications

MMP-1
Purified
Immunohistochemistry, KnockDown, Western Blot
Mouse
Protein A or G purified from cell culture supernatant
RUO
Supplied as a solution in PBS. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with No Preservative
36665R
Unconjugated
IgG1
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
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