Invitrogen™ MMP12 Recombinant Rabbit Monoclonal Antibody (1O3A4)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542836

Catalog No. PIMA542836

Description

Positive test controls include: A-549, BxPC-3, Mouse lung, Mouse brain, Mouse spleen, Rat lung. The target is usually found in the following locations: Secreted, extracellular matrix, extracellular space. Immunogen sequence: FGFPNFVKKI DAAVFNPRFY RTYFFVDNQY WRYDERRQMM DPGYPKLITK NFQGIGPKID AVFYSKNKYY YFFQGSNQFE YDFLLQRITK TLKSNSWFGC.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22. 3.

Specifications

• Antigen: MMP12
• Classification: Recombinant Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P34960, P39900, Q63341
• Gene Symbols: Mmp12
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 371-470 of human MMP12 (P39900).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 1O3A4
• Conjugate: Unconjugated
• Gene: Mmp12
• Gene Alias: 3.4.24.65; AV378681; HME; Macrophage elastase; macrophage metalloelastase; macrophage-metalloelastase; matrix metallo protease; matrix metallopeptidase 12; matrix metallopeptidase 12 (macrophage elastase); matrix metalloproteinase 12; matrix metalloproteinase 12 (macrophage elastase); matrix metalloproteinase-12; ME; MGC138506; MME; Mmel; MMP; Mmp12; MMP-12; MMPs
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 117033, 17381, 4321
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid