MMP14 Mouse anti-Human, Clone: 133CT188.8.131.52, Abnova™
Mouse monoclonal antibody raised against synthetic peptide of human MMP14.
Manufacturer: Abnova Corporation MAB12762
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq]
|Mouse monoclonal antibody raised against synthetic peptide of human MMP14.|
|In PBS (0.09% sodium azide).|
|Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|Immunofluorescence, Western Blot|
|Immunofluorescence (1:10 - 1:50) Western Blot (1:100 - 1:500) The optimal working dilution should be determined by the end user.|
|A synthetic peptide (conjugated with KLH) corresponding to amino acids 470-499 at C-terminus region of human MMP14.|
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