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Invitrogen™ MMP19 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534748

Catalog No. PIPA534748


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Description

Description

Recommended positive controls: human synovial fluid, MMP19-transfected 293T. Predicted reactivity: Rat (81%), Bovine (85%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

MMP-19 (RASI-1, MMP-18) is a 508 amino acid peptide, originally isolated as an autoantigen from the synovium of a patient suffering from rheumatoid arthritis (RA). Its presence on the surface of activated PBMCs, TH1 lymphocytes, and Jurkat T lymphoma cells in the synovium of acute RA patients, suggests that MMP-19 plays a role in RA-associated joint tissue destruction. MMP-19 exists in the smooth muscle cells of the tunica media of large blood vessels of the RA patient, but not in the endothelial cell layer. Acutely inflamed tissue synovial capillaries strongly express MMP-19 in the cytoplasm. Regulated induction of MMP-19 in capillary endothelial cells during acute inflammation suggest a role in angiogenesis. MMP-19 is a single 2.7kb transcript found in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis, colon, and heart.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

MMP19
Polyclonal
Unconjugated
MMP19
CODA; matrix metallo protease; matrix metallopeptidase 19; matrix metalloproteinase 19; matrix metalloproteinase RASI; Matrix metalloproteinase-18; matrix metalloproteinase-19; matrix metalloproteinase-beta19; MMP; MMP18; MMP-18; Mmp19; MMP-19; MMPs; Rasi; RASI-1
Rabbit
Antigen Affinity Chromatography
RUO
4327
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Q99542
MMP19
Recombinant fragment corresponding to a region within amino acids 210 and 508 of MMP19 (Uniprot ID#Q99542).
100 μL
Primary
Human
Antibody
IgG
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