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MMP19 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Supplier: Proteintech Group Inc 142441AP150UL
Description
MMP-19 (RASI-1, MMP-18) is a 508 amino acid peptide, originally isolated as an autoantigen from the synovium of a patient suffering from rheumatoid arthritis (RA). Its presence on the surface of activated PBMCs, TH1 lymphocytes, and Jurkat T lymphoma cells in the synovium of acute RA patients, suggests that MMP-19 plays a role in RA-associated joint tissue destruction. MMP-19 exists in the smooth muscle cells of the tunica media of large blood vessels of the RA patient, but not in the endothelial cell layer. Acutely inflamed tissue synovial capillaries strongly express MMP-19 in the cytoplasm. Regulated induction of MMP-19 in capillary endothelial cells during acute inflammation suggest a role in angiogenesis. MMP-19 is a single 2.7kb transcript found in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis, colon, and heart.Specifications
MMP19 | |
Polyclonal | |
Unconjugated | |
MMP19 | |
matrix metallopeptidase 19, Matrix metalloproteinase 18, Matrix metalloproteinase 19, Matrix metalloproteinase RASI, MMP 18, MMP 19, MMP18, MMP19, RASI, RASI 1 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
304608, 4327, 58223 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
0.3 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
Q99542, Q9JHI0 | |
MMP19 | |
MMP19 Fusion Protein Ag5501 | |
150 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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